Radiotherapy induces an immediate inflammatory reaction in malignant glioma: a clinical microdialysis study
نویسندگان
چکیده
منابع مشابه
Immediate post-radiotherapy changes in malignant glioma can mimic tumor progression.
To determine the frequency of progressive MRI lesions shortly after radiotherapy for glioma with spontaneous improvement or stabilization, the authors studied a cohort of patients treated within two prospective phase III trials with radiotherapy only. In 9 out of 32 patients, the first post-radiotherapy MRI showed progressive enhancement. In 3 of these 9 the MRI improved or stabilized for 6 mon...
متن کاملInflammatory demyelinating disease mimicking malignant glioma.
UNLABELLED The differential diagnosis between inflammatory demyelinating disease and malignant glioma is difficult based only on neuroimaging methods. METHODS Four patients with inflammatory demyelinating disease who presented with clinical and neuroimaging findings strongly suggestive of malignant glioma were examined. RESULTS MRI showed a mass lesion with prolonged T1 and T2 values and ga...
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Sixty patients with the diagnosis of supratentorial malignant glial tumor, treated between November 1993-June 1997, were retrospectively analyzed. The patients had a median age of 47 years and a median Karnofsky Performance Status score of 90. Histology consisted of anaplastic astrocytoma in 21 (35%) and glioblastoma multiforme in 39 (65%) patients. Median survival was 13 months for all patient...
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BACKGROUND Hyperactivation of the mTORC2 signaling pathway has been shown to contribute to the oncogenic properties of gliomas. Moreover, overexpression of the mTORC2 regulatory subunit Rictor has been associated with increased proliferation and invasive character of these tumor cells. METHODOLOGY/PRINCIPAL FINDINGS To determine whether Rictor overexpression was sufficient to induce glioma fo...
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The progression of glioma to more malignant phenotypes results from the stepwise accumulation of genetic alterations and the consequent disruption of the apoptotic pathway and augmentation of survival signaling. REIC/Dkk-3, a member of the human Dickkopf (Dkk) family, plays a role as a suppressor of the growth of several human cancers; however, to date it has not been identified in brain tumors...
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ژورنال
عنوان ژورنال: Journal of Neuro-Oncology
سال: 2016
ISSN: 0167-594X,1573-7373
DOI: 10.1007/s11060-016-2271-1